All-inclusive 3D Osteogenesis-Angiogenesis Coupling Kit

Bone formation and repair is a complex process involving the highly orchestrated interplay between different cell types, such as endothelial cells and osteoblasts. During skeletal development and postnatal bone repair, angiogenesis and osteogenesis must be tightly coupled for physiological bone function, as blood vessels bring a supply of oxygen, nutrients and osteogenic progenitor cells into the osteogenic environment. In fact, the absence of a functional vasculature network can compromise physiological bone healing, leading to osteonecrosis, osteoporosis, and non-union fractures. Thus, elucidation of the molecular crosstalk between angiogenesis and osteogenesis is critical in designing the therapeutic strategies for improving efficient vascularization and bone formation. To study such complex tissue and regulation processes, ScienCell’s 3D Osteogenesis-Angiogenesis Coupling kit (3D-OAC) is designed to co-culture human primary osteoblasts and endothelial cells as 3D multicellular spheroids, mimicking the complex cellular interactions present in bone tissue.