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cardiac myocytes

 

Cardiac myocytes are highly specialized cells critical for the rhythmic contraction of the heart muscle. Differentiated cardiac myocytes have little proliferation capacity, resulting in less than 50% of cell replacement throughout the human lifespan [1]. In contrast, cardiac fibroblasts are highly proliferative, and the presence of even a few proliferating fibroblasts can quickly outnumber non-proliferating myocytes in primary culture. In addition, most commercially available cardiac myocyte medium for primary cardiac myocytes contains serum, which can further promote fibroblast outgrowth.  Due to the challenges associated with culturing primary cardiac myocytes, ScienCell has developed Cardiac Myocyte Medium–Serum Free to support cardiac myocytes in culture while limiting cardiac fibroblast proliferation.

Primary cardiac myocytes are an important tool for studying the molecular mechanisms of cardiac myocyte biology and hypertrophy. A deeper understanding of cardiac myocyte functionality may lead to the development of new treatments for heart failure.

[1] Bergmann O, Bhardwaj RD, Bernard S, Zdunek S, Barnabe-Heider F, Walsh S, Zupicich J, Alkass K, Buchholz BA, Druid H, Jovinge S and Frisen J. (2009) “Evidence for cardiomyocyte renewal in humans.” Science. 324: 98-102.

 

  1. Human Cardiac Myocytes (HCM) – Immunostaining for Sarcomeric alpha-Actinin (Boster, Cat #MA1104)

    Cat #6200: Human Cardiac Myocytes

    Isolated from human heart. HCM are cryopreserved after purification and delivered frozen. Each vial contains >1 x 10^6 cells in 1 ml volume.

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  2. Mouse Cardiac Myocytes (MCM) – Immunostaining for Tropomyosin (Sigma, Cat #T9283)

    Cat #M6200: Mouse Cardiac Myocytes from CD1

    Isolated from postnatal day 2 mouse heart. MCM are cryopreserved at P0 and delivered frozen. Each vial contains >1 x 10^6 cells in 1 ml volume.

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    Rat Cardiac Myocytes (R6200)

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  3. Mouse Cardiac Myocytes (MCM) – Immunostaining for Sarcomeric alpha-Actinin (Boster, Cat #MA1104)

    Cat #M6200-57: Mouse Cardiac Myocytes from C57BL/6

    Isolated from postnatal day 2 C57BL/6 mouse heart. MCM are cryopreserved at P0 and delivered frozen. Each vial contains >1 x 10^6 cells in 1 ml volume. Learn More
  4. Rat Cardiac Myocytes (RCM) – Immunostaining for Sarcomeric alpha-Actinin (Boster, Cat #MA1104)

    Cat #R6200: Rat Cardiac Myocytes

    Isolated from postnatal day 2 rat heart. RCM are cryopreserved at P0 and delivered frozen. Each vial contains >1 x 10^6 cells in 1 ml volume.

    You might also be interested in:
    Mouse Cardiac Myocytes from CD1 (M6200)

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  5. Cardiac Myocyte Medium-serum free

    Cat #6101: Cardiac Myocyte Medium-serum free

    CMM-sf consists of 500 ml of basal medium, 5 ml of Cardiac Myocyte Growth Supplement-serum free (CMGS-sf, Cat. #6152) and 5 ml of penicillin/streptomycin solution (P/S, Cat. #0503).

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  6. Cardiac Myocyte Growth Supplement-serum free

    Cat #6152: Cardiac Myocyte Growth Supplement-serum free

    CMGS-sf is for research use only. It is not approved for human or animal use, or for application in in vitro diagnostic procedures. Learn More

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