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- GeneQuery™ Human Autism Spectrum Disorder qPCR Array Kit
ScienCell’s GeneQuery™ Human Autism Spectrum Disorder qPCR Array Kit (GQH-ASD) profiles 88 key genes associated with Autism Spectrum Disorder. Autism Spectrum Disorder is a developmental disability that can result in social, communication, behavioral, and learning challenges. The disease is early-appearing, with symptoms often presenting early in childhood, and evidence suggests there is a strong hereditary component. Brief examples of how included genes may be grouped according to their functions are shown below:
- Neurodevelopment: ADNP, ARID1B, CHD2, DISC1, DSCAM, FOXP1, KMT2C, RIMS, TCF4, ZBTB20, ANKRD11, ASH1L, ASXL3, AUTS2, BCL11A, CACNA1H, GRIN2B, KATNAL2, KDM6B, MET, NCKAP1, NRXN3, PHF2, POGZ, RBFOX1, RELN, SEMA5A, SHANK2
- Impaired communication/behavioral ability: CNTNAP2, FOXP2, GRIK2, KMT2A, MACROD2, MED13L, PAX5, PTEN, SHANK3, SPAST, KMT5B
- Social deficits/behavioral abnormalities: AVPR1A, BCKDK, CNTNAP4, DIP2A, GRIP1, HMGN1
- Calcium signaling/calcium channels: ATP2B2, CACNB2, CDC42BPB, PRKCB
- Altered expression linked to ASD: FOXP1, GABRB3, TRIO, ZMYND11, CHRNA7, KDM5B, SETBP1, SYNGAP1, TBR1, TRIP12, WAC, WDFY3, ASTN2, CACNA2D3, CHD8, CTCF, CTTNBP2, GPHN, GRIP1, MBD5, MYT1L, NLGN3, NR3C2, NRXN1, PTCHD1, SETD5
- Novel variants found in ASD: DEAF1, MAGEL2, TNRC6B, TRPC6
- Other risk factors for Autism: CACNA1D, CHD8, CUL3, MACROD2, SCN2A, OXTR, SCN2A, SLC9A9, CTNND2, MECP2
- Linked to non-syndromic autism: ANK2, KMT2E, NLGN4X, TRPC6, SHANK3
GeneQuery™ qPCR array kits are qPCR ready in a 96-well plate format, with each well containing one primer set that can specifically recognize and efficiently amplify a target gene's cDNA. The carefully designed primers ensure that: (i) the optimal annealing temperature in qPCR analysis is 65°C (with 2 mM Mg2+, and no DMSO); (ii) the primer set recognizes all known transcript variants of target gene, unless otherwise indicated; and (iii) only one gene is amplified. Each primer set has been validated by qPCR with melt curve analysis, and gel electrophoresis.
Catalog No. | GK077 |
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Country of Manufacture | United States |
Product Code | GQH-ASD |
Size/Quantity | One 96-well plate, one 20ul reaction per well |
Product Use | GQH-ASD is for research use only. It is not approved for human or animal use, or for application in clinical or in vitro diagnostic procedures. |
Storage | Upon receipt, the plate should be stored at 4°C and is good for up to 12 months. For long-term storage (>1 year), store the plate at -20°C in a manual defrost freezer. |
Shipping Info | The product is shipped at ambient temperature. |
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