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Need help with product selection and ordering?
Email us at sales@sciencellonline.com
Need help with scientific inquiries, technical assistance, product applications, and use?
Email us at techsupport@sciencellonline.com
Need help with issues concerning this website?
Email us at webmaster@sciencellonline.com
Have any marketing related inquiries?
Email us at marketing@sciencellonline.com
Need help ordering from abroad?
As the largest cell provider, we are available worldwide.
Please visit our Distributors page to select the company nearest to your location.
We are located at 1610 Faraday Ave, Carlsbad, CA 92008
Call us at (877) 602-8549 or (760) 602-8549
Fax us at (760) 602-8575
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ScienCell's GeneQuery™ Human CTLA4 Checkpoint Pathway qPCR Array Kit (GQH-CTL) is designed to facilitate gene expression profiling of 88 key genes involved in the human CTLA4 checkpoint pathway and to help identify potential prognostic biomarkers for cancer immunotherapy. CTLA4 is a negative regulator of T cell immune function. It regulates T cell priming in the initial stage of antigen stimulation. CTLA4 can antagonize CD28 signaling in T cells, as CTLA4 and CD28 compete for the same binding ligands, CD80 and CD86. Cancer immunotherapy using CTLA4 immune-checkpoint blockade (ICB) has emerged as a promising strategy to activate antitumor T cell responses, and has led to new immunotherapies for various solid and hematological tumors. Brief examples of how genes may be grouped according to their functions are shown below:
GeneQuery™ qPCR array kits are qPCR ready in a 96-well plate format, with each well containing one primer set that can specifically recognize and efficiently amplify a target gene's cDNA. The carefully designed primers ensure that: (i) the optimal annealing temperature in qPCR analysis is 65°C (with 2 mM Mg2+, and no DMSO); (ii) the primer set recognizes all known transcript variants of target gene, unless otherwise indicated; and (iii) only one gene is amplified. Each primer set has been validated by qPCR with melt curve analysis, and gel electrophoresis.
Note: all gene names follow their official symbols by the Human Genome Organization Gene Nomenclature Committee (HGNC).
Common synonyms of selected genes | ||||
---|---|---|---|---|
Official symbol | Synonym(s) | Official symbol | Synonym(s) | |
PDCD1 | PD-1, CD279 | NCOR2 | TRAC | |
CD274 | PD-L1, B7-H | NFATC2 | NFAT1 | |
PDCD1LG2 | PD-L2, CD273 | PTCRA | PTA | |
CARD11 | CARMA1 | PTPN11 | SHP1 | |
CD80 | B7-1 | PTPN6 | SHP2 | |
CD86 | B7-2 | TNFRSF18 | GITR | |
CD276 | B7-H3 | TNFRSF4 | OX40, CD134 | |
ICOS | CD278 | TNFRSF9 | CD137 | |
ICOSLG | B7-H2 | TRAT1 | TRIM |
Catalog No. | GK122 |
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Country of Manufacture | United States |
Product Code | GQP-CTL |
Size/Quantity | - |
Product Use | This product is for research use only. It is not approved for use in humans, animals, or in vitro diagnostic procedures. |
Storage | - |
Shipping Info | - |
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