GeneQuery™ Human Schizophrenia qPCR Array Kit

ScienCell’s GeneQuery™ Human Schizophrenia qPCR Array Kit (GQH-SCZ) profiles 88 key genes involved in the development and progression of schizophrenia. Schizophrenia is a chronic mental disorder characterized by altered mood, thought, and behavior. Both environmental and genetic factors contribute to the risks of developing schizophrenia and the symptoms can be debilitating. Current treatments mainly focus on relieving symptoms because the exact underlying mechanisms causing schizophrenia are still unknown. Below are brief examples of how included genes may be grouped according to their function:

• Susceptibility: GRM3, DISC1, DAOA, RGS4, NRG1
• Early onset schizophrenia: DRD3, HTR3A, NDUFS4, SOX10, BDNF
• Paranoid schizophrenia: HTR2A, COMT, PRL, MAOA, CCKAR

GeneQuery™ qPCR array kits are qPCR ready in a 96-well plate format, with each well containing one primer set that can specifically recognize and efficiently amplify a target gene's cDNA. The carefully designed primers ensure that: (i) the optimal annealing temperature in qPCR analysis is 65°C (with 2 mM Mg²⁺, and no DMSO); (ii) the primer set recognizes all known transcript variants of target gene, unless otherwise indicated; and (iii) only one gene is amplified. Each primer set has been validated by qPCR with melt curve analysis, and gel electrophoresis.