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Need help with product selection and ordering?
Email us at sales@sciencellonline.com
Need help with scientific inquiries, technical assistance, product applications, and use?
Email us at techsupport@sciencellonline.com
Need help with issues concerning this website?
Email us at webmaster@sciencellonline.com
Have any marketing related inquiries?
Email us at marketing@sciencellonline.com
Need help ordering from abroad?
As the largest cell provider, we are available worldwide.
Please visit our Distributors page to select the company nearest to your location.
We are located at 1610 Faraday Ave, Carlsbad, CA 92008
Call us at (877) 602-8549 or (760) 602-8549
Fax us at (760) 602-8575
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Heparin is a 10-12 kDa polysaccharide produced in mast cells. Heparin inhibits blood coagulation through binding and activation of anti-thrombin [1] and acts as a cofactor to basic Fibroblast Growth Factor-2 (bFGF) [2, 3, 4].
The effect of heparin on cell growth and morphology in vitro is cell-type dependent and may promote or inhibit cell proliferation. Culture media may be supplemented with heparin solution (HEP) at 1:1000-1:100 (0.36 – 3.6 U/mL). The optimal concentration should be determined for individual cell types and culture conditions.
Concentration
2 mg/mL heparin sodium salt (from porcine intestinal mucosa) in Dulbecco’s Phosphate-Buffered Saline, sterile-filtered. Potency: > 180 Units per milligram*.
*Units are USP (United States Pharmacopeia units) and indicate heparin potency by weight. Units are not evaluated by ScienCell but are provided by supplier.
Catalog No. | 0863 |
---|---|
Country of Manufacture | United States |
Product Code | HEP |
Size/Quantity | 5 ml |
Product Use | This product is for research use only. It is not approved for use in humans, animals, or in vitro diagnostic procedures. |
Storage | Store at 4°C. |
Shipping Info | Gel ice. |
References | [1] Bjork I and Lindahl U. (1982) "Mechanism of the anticoagulant action of heparin". Mol Cell Biochem, 48(3):161-82. [2] Rapraeger AC, Krufka A and Olwin BB. (1991) "Requirement of heparin sulfate for bFGF-mediated fibroflast growth and myoblast differentiation". Science. 252(5013):1705-8. [3] Roghani M, Mansukhani A, et al. (1994) "Heparin increases the affinity of basic fibroblast growth factor for its receptor but is not required for binding". J Biol Chem. 269(6):3976-84. [4] Sasisekharan R, Ernst S and Venkataraman G. (1997) "On the regulation of fibroblast growth factor activity by heparin-like glycosaminoglycans". Angiogenesis, 1(1):45-54. |
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