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- Human Adrenal Microvascular Endothelial Cells
The adrenal gland plays an essential role in regulating homeostasis in the body through the secretion of corticosteroid and androgen hormones. The secreted steroids arise from the three zones of the adrenal gland: the zona glomerulosa, zona fasciculate, and zona reticularis. Microvascular endothelial cells (MEC) line the blood vessels and contribute to many biological processes such as hemostasis, coagulation, trafficking of lymphocytes, and the inflammatory response. MEC regulate the secretion of adrenal hormones in the adrenal gland. Studies have shown that factors secreted from HAdMEC, such as endothelin-1, nitric oxide, adrenomedullin and proadrenomedullin NH2-terminal 20 peptide affect aldosterone secretion. HAdMEC, unlike brain and liver MECs, are highly resistant to glucocorticoid-induced cytotoxicity.
HAdMEC from ScienCell Research Laboratories are isolated from human adrenal tissue. HAdMEC are cryopreserved at passage one and delivered frozen. Each vial contains >5 x 10⁵ cells in 1 ml volume. HAdMEC are characterized by immunofluorescence with antibodies specific to vWF/Factor VIII and/or CD31 (PECAM1). HAdMEC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HAdMEC are guaranteed to further culture for 15 population doublings under the conditions provided by ScienCell Research Laboratories.
Recommended Medium
It is recommended to use Endothelial Cell Medium (ECM, Cat. #1001) for the culturing of HAdMEC in vitro.
| Catalog No. | 3600 |
|---|---|
| Country of Manufacture | United States |
| Product Code | HAdMEC |
| Size/Quantity | 5 x 10⁵ cells/vial. |
| Product Use | HAdMEC are for research use only. They are not approved for human or animal use, or for application in in vitro diagnostic procedures. |
| Storage | Upon receiving, directly and immediately transfer the cells from dry ice to liquid nitrogen and keep the cells in liquid nitrogen until they are needed for experiments. |
| Shipping Info | Dry ice. |
| References | [1][2] Hinson, J.P., Kapas, S. 1998. The role of endothelial cell product in the regulation of adrenocortical functions: actions of endothelin, nitric oxide, adrenomedullin and PAMP. Horm Metab Res. 30(6-7): 334-40 [3] Gu, F., Zhang, WJ., Wu, LQ., Ye, LY., Li, HZ., Li, J., Xu, SQ., XU, YP., Lou, JN. 2006. Characteristics of human adrenal microvascular endothelial cells in morphology, phenotypes, and function. Ahonqquo Yi Xue Ke Xue Yuan Xue Bao. 28(4):502-6 |
3600No Publication available at this time
| CAT. NO. | CODE | DESCRIPTION | PRICE | Qty | |
|---|---|---|---|---|---|
| MEDIA | |||||
| 1001 | ECM | Endothelial Cell Medium |
$139.00
As low as:
$92.00
|
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| 8248 | BPF | Bovine Plasma Fibronectin |
$137.00
|
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| MOLECULAR BIOLOGY | |||||
| 3604 | HAdMEC cDNA | Human Adrenal Microvascular Endothelial Cell cDNA |
$453.00
|
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| 3605 | HAdMEC tRNA | Human Adrenal Microvascular Endothelial Cell Total RNA |
$401.00
|
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| 3606 | HAdMEC Lysate | Human Adrenal Microvascular Endothelial Cell Lysate |
$438.00
|
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| 3607 | HAdMEC miRNA | Human Adrenal Microvascular Endothelial Cell MicroRNA |
$374.00
|
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| 3609 | HAdMEC gDNA | Human Adrenal Microvascular Endothelial Cell genomic DNA |
$438.00
|
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