Human Cellular Fibronectin

Fibronectin is a multi-domain glycoprotein composed of an array of multiple repeated modular structures. Cellular fibronectin, an adhesion glycoprotein of the extracellular matrix, exists as a dimer with a molecular mass of ~ 550 kDa. This structure is composed of two heterodimers, the A chain and the B chain containing the type III connecting segment region. Cellular fibronectin differs from plasma fibronectin by the presence of additional polypeptide segments and its capacity to specifically regulate morphology and growth of attached cells including stem cells [1, 2, 3, 4]. Multiple domains of fibronectin show binding affinities for collagen, fibrin, heparin, and specific cell membrane receptors such as integrins. Fibronectin matrix assembly is essential for normal development and contributes to the generation of tumor metastases.

ScienCell^TM Human Cellular Fibronectin (HCF) is produced from human fibroblasts maintained in serum-free media and then purified biochemically. HCF is supplied sterile in CAPS saline buffer.

Product Specification

Quantity: 0.1 mg

Concentration: 0.5 mg/ml

Storage buffer: CAPS saline buffer, pH 11.

Catalog No.	8488
Country of Manufacture	United States
Product Code	HCF
Size/Quantity	100 μg
Product Use	This product is for research use only. It is not approved for use in humans, animals, or in vitro diagnostic procedures.
Storage	It is recommended to store the product as single use aliquots at -80°C. Thawing should be done slowly at 2-8°C with no agitation. Material that fails to dissolve can be removed by centrifugation. Avoid repeating freeze/thaw cycles.
Shipping Info	Dry ice.
References	1. Yamada KM and Akiyama SK (1984). In Methods for preparation of media, supplements and substrata for serum-free animal cell culture. pp. 215-30. Alan R. Liss, Inc., New York. 2. Akiyama S et al. (1985). Fibronectin and fibronectin fragments in Extracellular Matrix: A Practical Approach, (New York), p. 183. 3. Potts JR and Campbell ID (1994). Fibronectin Structure and Assembly. Curr. Cell Bio, 6: 648-655. 4. Singh P, Schwarzbauer JE (2012). Fibronectin and stem cell differentiation - lessons from chondrogenesis. J Cell Sci, 15: 3703-12.

Product Sheets

8488

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1.) Xie, F., Li, Z.P., Wang, H.W., Fei, X., Jiao, Z.Y., Tang, W.B., Tang, J. & Luo, Y.K. (2016) Evaluation of Liver Ischemia-Reperfusion Injury in Rabbits Using a Nanoscale Ultrasound Contrast Agent Targeting ICAM-1 PLoS One. 11

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Catalog #8488

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