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- Human Hair Outer Root Sheath Cells
The outer root sheath (ORS) of the hair follicle surrounds the hair fiber and inner root sheath. It is derived from the epidermis by downward growth. The ORS consists of basal, prickle cells and granular layers near the opening of the follicle onto the skin surface, and modified glycogen-rich prickle cells in the deeper parts of the follicle. The ORS contains several cell populations which play a role in certain functions of the hair follicle, such as serving as a sensory organ and an immunologic sentinel of the skin. A previous study showed that the ORS contains nestinexpressing stem cells, with a variable location of the nestin-expressing stem cells based on the hair cycle. The ORS further represents an alternate source of keratinocytes, which are suitable for skin replacement.
HHORSC from ScienCell Research Laboratories are isolated from human scalp. HHORSC are cryopreserved at passage one and delivered frozen. Each vial contains >5 x 10^5 cells in 1 ml volume. HHORSC are characterized by their mesenchymal cell morphology and immunofluorescence with antibodies specific to fibronectin and/or CD105. HHORSC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi. HHORSC are guaranteed to further expand for 10 population doublings under the conditions provided by ScienCell Research Laboratories.
Recommended Medium
It is recommended to use Mesenchymal Stem Cell Medium (MSCM, Cat. #7501) for culturing HHORSC in vitro.
| Catalog No. | 2420 |
|---|---|
| Country of Manufacture | United States |
| Product Code | HHORSC |
| Size/Quantity | 5 x 10^5 cells/vial |
| Product Use | This product is for research use only. It is not approved for use in humans, animals, or in vitro diagnostic procedures. |
| Storage | Directly and immediately transfer cells from dry ice to liquid nitrogen upon receiving and keep the cells in liquid nitrogen until cell culture needed for experiments. |
| Shipping Info | Dry ice. |
| References | [1] Stevens A, Lowe J. (1991) "Skin and Breast: Skin Appendages." In Histology (pp. 356-357). London: Gower Medical Publishing. [2] Paus R, Cotsarelis G. (1999) "The biology of hair follicles." N Engl J Med. 341: 491-7. [3] Li L, Mignone J, Yang M, Matic M, Penman S, Enikolopov G, Moffman R. (2003) "Nestin expression in hair follicle sheath progenitor cells." PNAS. 100: 9958-61. [4] Limat A, Breitkreutz D, Thiekoetter G, Klein CE, Braathen LR, Hunziker T, Fusenig NE. (1995) "Formation of a regular neo-epidermis by cultured human outer root sheath cells grafted on nude mice." Transplantation. 59: 1032-8. |
2420-
Excellent Review by Dina
Ease-of-use Overall quality of the product Technical resources When we need any Human Hair Outer Root Sheath Cells - order it from Sciencell. (Posted on 7/15/2020)
1.) Zhao, Z., Liu, G., Li, X., Huang, J., Xiao, Y., Du, X. & Yu, M. (2016) Characterization of the Promoter Regions of Two Sheep Keratin-Associated Protein Genes for Hair Cortex-Specific Expression PLoS One. 11
2.) Panicker SP, Ganguly T, Consolo M, Price V, Mirmirani P, Honda K, Karnik P. (2012) "Sterol intermediates of cholesterol biosynthesis inhibit hair growth and trigger an innate immune response in cicatricial alopecia." PLoS One. 7: e38449.
3.) Karnik P, Tekeste Z, McCormick TS, Gilliam AC, Price VH, Cooper KD, Mirmirani P. (2009) "Hair follicle stem cell-specific PPARgamma deletion causes scarring alopecia." J Invest Dermatol. 129: 1243-57.
ScienCell Research Laboratories (SRL) takes pride in being a resource for researchers all over the world. The publications listed here are not meant as an endorsement or confirmation of the reliability of the research methods. Our sole intention of sharing the research publications listed here is to provide research related insights and innovations of our products with other researchers.
| CAT. NO. | CODE | DESCRIPTION | PRICE | Qty | |
|---|---|---|---|---|---|
| 2429 | HHORSC gDNA | Human Hair Outer Root Sheath Cell genomic DNA |
$438.00
|
