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- Human Mammary Vascular Endothelial Cells
Vascular endothelial cells lining the blood vessels actively participate in many vital biological processes. Studies have shown that mammary vascular endothelial cells (MVEC) secrete a mammary-derived growth inhibitor to modulate endothelial cell proliferation and differentiation of the mammary gland. MVEC also regulate trafficking of lymphocytes and the inflammatory response, and are thus implicated in mastitis. Further studies demonstrate a critical role for MVEC in breast cancer development through angiogenesis. Human MVEC (HMVEC) cultures are a great model for identifying targets for therapeutic development in breast cancer.
HMVEC from ScienCell Research Laboratories are isolated from human breast. HMVEC are cryopreserved after purification and delivered frozen. Each vial contains >5 x 10^5 cells in 1 ml volume. HMVEC are characterized by immunofluorescence with antibodies specific to vWF/Factor VIII and CD31 (PECAM), and by uptake of DiI-Ac-LDL. HMVEC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi. HMVEC are guaranteed to further expand for 10 population doublings under the conditions provided by ScienCell Research Laboratories.
Recommended Medium
It is recommended to use Endothelial Cell Medium (ECM, Cat. #1001) for culturing HMVEC in vitro.
| Catalog No. | 7600 |
|---|---|
| Country of Manufacture | United States |
| Product Code | HMVEC |
| Size/Quantity | 5 x 10^5 cells/vial |
| Product Use | This product is for research use only. It is not approved for use in humans, animals, or in vitro diagnostic procedures. |
| Storage | Directly and immediately transfer cells from dry ice to liquid nitrogen upon receiving and keep the cells in liquid nitrogen until cell culture needed for experiments. |
| Shipping Info | Dry ice. |
| References | [1] KM. Ahem, MR. Davis & IM. Sordillo (1995) Isolation and characterization of bovine mammary endothelial cells. Method in Cell Science. 17(1):41-46. [2] AG. Naccarato, P. Viacava, G. Bocci, G. Fanelli, P. Aretini, A. Lonobile, G. Montruccoli and G. Bevilacqua (2003) Definition of the microvascular pattern of the normal human adult mammary gland. J. Anat. 203:599-603. [3] V. Sigurdsson, AJR. Fridriksdottir. J. Kjartansson, JG. Jonasson, M. Steinarsdottir, OW. Petersen, HM. Ogmundsdottir, and T Gudjsonsson (2006) Human breast microvascular endothelial cells retain phenotypic traits in long-ter finite life span culture. In Vitro Cellular & Developmental Biology - Animal 42(10):332-340. |
76001.) Li, W., Zheng, Y., Zhao, X., Ge, Y., Chen, T., Liu, Y. & Zhou, Y. (2016) Osteoinductive Effects of Free and Immobilized Bone Forming Peptide-1 on Human Adipose-Derived Stem Cells PLoS One. 11
2.) Lee, M.S., Yuan, H., Jeon, H., Zhu, Y., Yoo, S., Shi, S., Krueger, B., Renne, R., Lu, C., Jung, J.U. & Gao, S.J. (2016) Human Mesenchymal Stem Cells of Diverse Origins Support Persistent Infection with Kaposi?s Sarcoma-Associated Herpesvirus and Manifest Distinct Angiogenic, Invasive, and Transforming Phenotypes mBio. 7
ScienCell Research Laboratories (SRL) takes pride in being a resource for researchers all over the world. The publications listed here are not meant as an endorsement or confirmation of the reliability of the research methods. Our sole intention of sharing the research publications listed here is to provide research related insights and innovations of our products with other researchers.
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| CAT. NO. | CODE | DESCRIPTION | PRICE | Qty | |
|---|---|---|---|---|---|
| MEDIA | |||||
| 1001 | ECM | Endothelial Cell Medium |
$126.00
As low as:
$83.00
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| REAGENTS | |||||
| 0103 | T/E | Trypsin/EDTA Solution (0.25%; 100ml) |
$21.00
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| 0113 | TNS | Trypsin Neutralization Solution, 100 ml |
$21.00
|
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| 0303 | DPBS | Dulbecco's Phosphate-Buffered Saline, 500 ml |
$16.00
|
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| 0903 | EndoF | EndoFectagen |
$253.00
|
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| 8248 | BPF | Bovine Plasma Fibronectin |
$124.00
|
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| MOLECULAR BIOLOGY | |||||
| 7604 | HMVEC cDNA | Human Mammary Vascular Endothelial Cell cDNA |
$411.00
|
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| 7605 | HMVEC tRNA | Human Mammary Vascular Endothelial Cell Total RNA |
$364.00
|
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| 7606 | HMVEC Lysate | Human Mammary Vascular Endothelial Cell Lysate |
$398.00
|
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| 7607 | HMVEC miRNA | Human Mammary Vascular Endothelial Cell MicroRNA |
$340.00
|
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| 7609 | HMVEC gDNA | Human Mammary Vascular Endothelial Cell Genomic DNA |
$398.00
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