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Meningeal cells surround the brain and actively participate in the development of the central nervous system. They play an important role in stabilizing the extracellular matrix of the pial surface, organizing the radial glial scaffold, and laminating the cerebellar cortex. Selective pharmacological destruction of the meningeal cells during a critical ontogenetic period leads to specific malformation of both the cerebellar cortex and dentate gyrus. Grafts of meningeal cells, which are derived from meninges overlying the cerebral cortex, in adult rat spinal cord lesions promotes axonal regrowth. Additionally, in vitro studies showed that meningeal cells
chemotactically orient the migration of immature neurons but not glial cells.
HMC from ScienCell Research Laboratories are isolated from human leptomeninges. HMC are cryopreserved at passage one and delivered frozen. Each vial contains >5 x 10^5 cells in 1 ml volume. HMC are characterized by immunofluorescence; they are positive for fibronectin and negative for GFAP and α-smooth muscle actin. HMC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi. HMC are guaranteed to further expand for 15 population doublings under the conditions specified by ScienCell Research Laboratories.
Recommended Medium
It is recommended to use Meningeal Cell Medium (MenCM, Cat. #1401) for culturing HMC in vitro.
| Catalog No. | 1400 |
|---|---|
| Country of Manufacture | United States |
| Product Code | HMC |
| Size/Quantity | 5 x 10^5 cells/vial |
| Product Use | This product is for research use only. It is not approved for use in humans, animals, or in vitro diagnostic procedures. |
| Storage | Directly and immediately transfer cells from dry ice to liquid nitrogen upon receiving and keep the cells in liquid nitrogen until cell culture needed for experiments. |
| Shipping Info | Dry ice. |
| References | [1] Hartmann, D., Sievers, J. Pehlemann, F. W. and Berry, M. (1992) Destruction of meningeal cells over the medial cerebral hemisphere of newborn hamster prevents the formation of the infrapyramidal blade of the dentate gyrus. J. Comparative Neurol. 320:33-61. [2] Franzen, R., Martin, D., Daloze, A., Moonen, G. and Schoenen, J. (1999) Grafts of meningeal fibroblasts in adult rat spinal cord lesion promote axonal regrowth. Neuroreport 10:1551-1556. [3] Hartmann, D., Schulze, M. and Sievers, J. (1998) Meningeal cells stimulate and direct the migration of cerebellar external granule cells in vitro. J. Neurocytol. 27:395-409. |
14001.) Diao Z, Ding J, Yin C, Wang L, Liu W. (2013) "Purified hepatitis B virus induces human Mesangial cell proliferation and extracellular matrix expression In Vitro." Virol j. 10: 300.
ScienCell Research Laboratories (SRL) takes pride in being a resource for researchers all over the world. The publications listed here are not meant as an endorsement or confirmation of the reliability of the research methods. Our sole intention of sharing the research publications listed here is to provide research related insights and innovations of our products with other researchers.
| CAT. NO. | CODE | DESCRIPTION | PRICE | Qty | |
|---|---|---|---|---|---|
| MEDIA | |||||
| 1401 | MenCM | Meningeal Cell Medium |
$132.00
As low as:
$90.00
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| MOLECULAR BIOLOGY | |||||
| 1404 | HMC cDNA | Human Meningeal Cell cDNA |
$453.00
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| 1405 | HMC tRNA | Human Meningeal Cell Total RNA |
$401.00
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| 1406 | HMC Lysate | Human Meningeal Cell Lysate |
$438.00
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| 1407 | HMC miRNA | Human Meningeal Cell MicroRNA |
$374.00
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| 1409 | HMC gDNA | Human Meningeal Cell genomic DNA |
$438.00
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