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- Human Ovarian Fibroblasts
Fibroblasts are mesenchymal cells derived from the embryonic mesoderm. They synthesize components of the extracellular matrix, maintain the structural integrity of connective tissues, and actively participate in wound healing. Accumulating evidence indicates that ovarian fibroblasts can be induced and activated by ovarian cancer cells to secrete a variety of growth factors, chemokines, collagens, and matrix-modifying enzymes to establish a pro-tumorigenic, anti-immunogenic niche for cancer progression and metastasis. These results suggest that fibroblasts play a stimulatory functional role in cancer development and invasive behavior.
HOF from ScienCell Research Laboratories are isolated from human ovary. HOF are cryopreserved at passage one and delivered frozen. Each vial contains >5 x 10^5 cells in 1 ml volume. HOF are characterized by their spindle morphology and immunofluorescence with antibody specific to fibronectin. HOF are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi. HOF are guaranteed to further expand for 15 population doublings under the conditions provided by ScienCell Research Laboratories.
Recommended Medium
It is recommended to use Fibroblast Medium (FM, Cat. #2301) for culturing HOF in vitro.
| Catalog No. | 7330 |
|---|---|
| Country of Manufacture | United States |
| Product Code | HOF |
| Size/Quantity | 5 x 10^5 cells/vial |
| Product Use | This product is for research use only. It is not approved for use in humans, animals, or in vitro diagnostic procedures. |
| Storage | Directly and immediately transfer cells from dry ice to liquid nitrogen upon receiving and keep the cells in liquid nitrogen until cell culture needed for experiments. |
| Shipping Info | Dry ice. |
| References | [1] Conrad, G. W., Hart, G. W., Chen, Y. (1977) Differences in vitro between fibroblast-like cells from cornea, heart, and skin of embryonic chicks. J. Cell Sci. 26:119-137. [2] Gabbiani, G., Rungger-Brandle, E., The fibroblast. In Tissue Repair and Regeneration (L. E. Glynn, ed.), pp 1-50. Handbook of Inflammation, Vol. 3. Amsterdam, Elsevier, 1981. [3] Westerlund A.,?Hujanen E.,Puistola U.,Turpeenniemi-Hujanen T. (1997) Ovarian fibroblasts stimulate human ovarian cancer cell invasion and expression of 72-kDa gelatinase A (MMP-2) Gynecologic Oncology 67(1)76-82. |
7330No Publication available at this time
| CAT. NO. | CODE | DESCRIPTION | PRICE | Qty | |
|---|---|---|---|---|---|
| 7334 | HOF cDNA | Human Ovarian Fibroblast cDNA |
$453.00
|
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| 7335 | HOF tRNA | Human Ovarian Fibroblast Total RNA |
$401.00
|
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| 7336 | HOF Lysate | Human Ovarian Fibroblast Lysate |
$438.00
|
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| 7337 | HOF miRNA | Human Ovarian Fibroblast MicroRNA |
$374.00
|
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| 7339 | HOF gDNA | Human Ovarian Fibroblast Genomic DNA |
$438.00
|
