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- Human Ovarian Surface Epithelial Cells
The ovary is covered by a single layer of surface epithelial cells (OSE) where in vivo morphology varies from squamous to cuboidal to low columnar. OSE actively participate in cyclical ovulatory follicular rupture and the subsequent repair. OSE express a variety of peptide hormones, sex steroids, growth factors, and receptors. Many of these biological agents have been implicated in the development of epithelial ovarian carcinomas and sexually transmitted infections. Understanding aberrations in the corresponding cellular pathways is of great clinical importance as they provide useful information regarding OSE cell survival, apoptosis, transformation, and function during disease development and potential markers for disease treatment.
HOSEpiC from ScienCell Research Laboratories are isolated from human ovary. HOSEpiC are cryopreserved at passage one and delivered frozen. Each vial contains >5 x 10^5 cells in 1 ml volume. HOSEpiC are characterized by immunofluorescence with antibodies specific to cytokeratin-18 and/or cytokeratin-19. HOSEpiC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi. HOSEpiC are guaranteed to further expand for 5 population doublings under the conditions provided by ScienCell Research Laboratories.
Recommended Medium
It is recommended to use Ovarian Epithelial Cell Medium (OEpiCM, Cat. #7311) for culturing HOSEpiC in vitro.
| Catalog No. | 7310 |
|---|---|
| Country of Manufacture | United States |
| Product Code | HOSEpiC |
| Size/Quantity | 5 x 10^5 cells/vial |
| Product Use | This product is for research use only. It is not approved for use in humans, animals, or in vitro diagnostic procedures. |
| Storage | Directly and immediately transfer cells from dry ice to liquid nitrogen upon receiving and keep the cells in liquid nitrogen until cell culture needed for experiments. |
| Shipping Info | Dry ice. |
| References | [1]. Murdoch WJ. (1995) Endothelial cell death in preovulatory ovine follicles: possible implication in the biomechanics of rupture. J Reprod Fertil 1995; 105:161-164. [2]. Katabuchi H, Okamura H. (2003) Cell biology of human ovarian surface epithelial cells and ovarian carcinogenesis. Medical Electron Microscopy 36(2):74-86. |
73101.) Halabi, N.M., Martinez, A., Al-Farsi, H., Mery, E., Puydenus, L., Pujol, P., Khalak, H.G., McLurcan, C., Ferron, G., Querleu, D., Al-Azwani, I., Al-Dous, E., Mohamoud, Y.A., Malek, J.A. & Rafii, A. (2016) Preferential Allele Expression Analysis Identifies Shared Germline and Somatic Driver Genes in Advanced Ovarian Cancer PLoS Genet. 12
2.) Lang, F., Qin, Z., Li, F., Zhang, H., Fang, Z. & Hao, E. (2015) Apoptotic Cell Death Induced by Resveratrol Is Partially Mediated by the Autophagy Pathway in Human Ovarian Cancer Cells PLoS One. 10
3.) Ibrahim, F.F., Jamal, R., Syafruddin, S.E., Ab Mutalib, N.S., Saidin, S., MdZin, R.R., Hossain Mollah, M.M. & Mokhtar, N.M. (2015) MicroRNA-200c and microRNA-31 regulate proliferation, colony formation, migration and invasion in serous ovarian cancer J Ovarian Res. 8
4.) Barger, C.J., Zhang, W., Hillman, J., Stablewski, A.B., Higgins, M.J., Vanderhyden, B.C., Odunsi, K. & Karpf, A.R. (2015) Genetic determinants of FOXM1 overexpression in epithelial ovarian cancer and functional contribution to cell cycle progression Oncotarget. 6
5.) Semaan A, Qazi AM, Seward S, Chamala S, Bryant CS, Kumar S, Morris R, Steffes CP, Bouwman DL, Mukarah AR, Weaver DW, Gruber SA, Batchu RB. (2011) "MicroRNA-101 Inhibits Growth of Epithelial Ovarian Cancer by Relieving Chromatin-Mediated Transcriptional Repression of p21waf1/cip1." Pharm Res. 28: 3079-90.
6.) Selvendiran K, Ahmed S, Dayton A, Kuppusamy ML, Tazi M, Bratasz A, Tong L, Rivera BK, K?lai T, Hideg K, Kuppusamy P. (2010) "Safe and targeted anticancer efficacy of a novel class of antioxidant-conjugated difluorodiarylidenyl piperidones: differential cytotoxicity in healthy and cancer cells." Free Radic Biol Med. 48: 1228-35.
7.) Selvendiran K, Tong L, Bratasz A, Kuppusamy ML, Ahmed S, Ravi Y, Trigg NJ, Rivera BK, K?lai T, Hideg K, Kuppusamy P. (2010) "Anticancer efficacy of a difluorodiarylidenyl piperidone (HO-3867) in human ovarian cancer cells and tumor xenografts." Mol Cancer Ther. 9: 1169-79.
ScienCell Research Laboratories (SRL) takes pride in being a resource for researchers all over the world. The publications listed here are not meant as an endorsement or confirmation of the reliability of the research methods. Our sole intention of sharing the research publications listed here is to provide research related insights and innovations of our products with other researchers.
| CAT. NO. | CODE | DESCRIPTION | PRICE | Qty | |
|---|---|---|---|---|---|
| MEDIA | |||||
| 7311 | OEpiCM | Ovarian Epithelial Cell Medium |
$135.00
As low as:
$90.00
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| MOLECULAR BIOLOGY | |||||
| 7314 | HOSEpiC cDNA | Human Ovarian Surface Epithelial Cell cDNA |
$453.00
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| 7315 | HOSEpiC tRNA | Human Ovarian Surface Epithelial Cell Total RNA |
$401.00
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| 7316 | HOSEpiC Lysate | Human Ovarian Surface Epithelial Cell Lysate |
$438.00
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| 7317 | HOSEpiC miRNA | Human Ovarian Surface Epithelial Cell MicroRNA |
$374.00
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| 7319 | HOSEpiC gDNA | Human Ovarian Surface Epithelial Cell Genomic DNA |
$438.00
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