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- Human Umbilical Vein Smooth Muscle Cells
Vascular smooth muscle cells (SMC) are primary contributors to the development of arterial disease. The ability of vascular SMC to switch to a proliferative phenotype is one of the main factors in the development and progression of vascular disease. Vascular smooth muscle cells express ICAM1 and VCAM-1, which may contribute to the inflammatory reaction in the vascular wall and may actively be involved in the progression of vascular disease. Vascular SMC in culture play an important role in vascular disease research and can be used to identify new therapeutic targets to treat arterial disease.
HUVSMC from ScienCell Research Laboratories are isolated from human umbilical veins. HUVSMC are cryopreserved at passage one and delivered frozen. Each vial contains >5 x 10⁵ cells in 1 ml volume. HUVSMC are characterized by immunofluorescence with antibodies specific to α-smooth muscle actin. HUVSMC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HUVSMC are guaranteed to further expand for 15 population doublings under the conditions provided by ScienCell Research Laboratories.
Recommended Medium
It is recommended to use Smooth Muscle Cell Medium (SMCM, Cat. #1101) for the culturing of HUVSMC in vitro.
| Catalog No. | 8020 |
|---|---|
| Country of Manufacture | United States |
| Product Code | HUVSMC |
| Size/Quantity | 5 x 10⁵ cells/vial. |
| Product Use | HUVSMC are for research use only. They are not approved for human or animal use, or for application in in vitro diagnostic procedures. |
| Storage | Upon receiving, directly and immediately transfer the cells from dry ice to liquid nitrogen and keep the cells in liquid nitrogen until they are needed for experiments. |
| Shipping Info | Dry ice. |
| References | [1] Schwartz, S. M., Campbell, G. R., Campbell, J. H. (1986) Replication of smooth muscle cells in vascular disease. Circ. Res. 58:427-444. [2] Braun, M., Pietsch, P., Schror, K., Baumann, G., Felix, S. B. (1999) Cellular adhesion molecules on vascular smooth muscle cells. Cardiovasc. Res. 41:395-401. |
1.) Liu, S., Guo, W., Han, X., Dai, W., Diao, Z. & Liu, W. (2016) Role of UBIAD1 in Intracellular Cholesterol Metabolism and Vascular Cell Calcification PLoS One. 11
2.) Li, J., Zhou, J., Zhang, D., Song, Y., She, J. & Bai, C. (2015) Bone marrow-derived mesenchymal stem cells enhance autophagy via PI3K/AKT signalling to reduce the severity of ischaemia/reperfusion-induced lung injury J Cell Mol Med. 19
3.) Li, Y., Guo, Y., Chen, Y., Wang, Y., You, Y., Yang, Q., Weng, X., Li, Q., Zhu, X., Zhou, B., Liu, X., Gong, Z. & Zhang, R. (2015) Establishment of an interleukin-1?-induced inflammation-activated endothelial cell-smooth muscle cell-mononuclear cell co-culture model and evaluation of the anti-inflammatory effects of tanshinone IIA on atherosclerosis Mol Med Rep. 12
ScienCell Research Laboratories (SRL) takes pride in being a resource for researchers all over the world. The publications listed here are not meant as an endorsement or confirmation of the reliability of the research methods. Our sole intention of sharing the research publications listed here is to provide research related insights and innovations of our products with other researchers.
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8020| CAT. NO. | CODE | DESCRIPTION | PRICE | Qty | |
|---|---|---|---|---|---|
| MEDIA | |||||
| 1101 | SMCM | Smooth Muscle Cell Medium |
$114.00
As low as:
$78.00
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| REAGENTS | |||||
| 0403 | PLL | Poly-L-Lysine, 1 mg/ml |
$16.00
|
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| 0303 | DPBS | Dulbecco's Phosphate-Buffered Saline, 500 ml |
$16.00
|
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| 0113 | TNS | Trypsin Neutralization Solution, 100 ml |
$21.00
|
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| 0103 | T/E | Trypsin/EDTA Solution, 0.25% |
$21.00
|
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| 0953 | SMCF | SMCFectagen |
$253.00
|
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| MOLECULAR BIOLOGY | |||||
| 8024 | HUVSMC cDNA | Human Umbilical Vein Smooth Muscle Cell cDNA |
$411.00
|
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| 8025 | HUVSMC tRNA | Human Umbilical Vein Smooth Muscle Cell Total RNA |
$364.00
|
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| 8026 | HUVSMC Lysate | Human Umbilical Vein Smooth Muscle Cell Lysate |
$398.00
|
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| 8027 | HUVSMC miRNA | Human Umbilical Vein Smooth Muscle Cell MicroRNA |
$340.00
|
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| 8029 | HUVSMC gDNA | Human Umbilical Vein Smooth Muscle Cell Genomic DNA |
$398.00
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