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How can we help you today?
Need help with product selection and ordering?
Email us at sales@sciencellonline.com
Need help with scientific inquiries, technical assistance, product applications, and use?
Email us at techsupport@sciencellonline.com
Need help with issues concerning this website?
Email us at webmaster@sciencellonline.com
Have any marketing related inquiries?
Email us at marketing@sciencellonline.com
Need help ordering from abroad?
As the largest cell provider, we are available worldwide.
Please visit our Distributors page to select the company nearest to your location.
We are located at 1610 Faraday Ave, Carlsbad, CA 92008
Call us at (877) 602-8549 or (760) 602-8549
Fax us at (760) 602-8575
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Microglia, one of the glial cell types in the central nervous system (CNS), is an important integral component of the neuro-glial cell network. They have been observed in the brain parenchyma from the early stage of development to the mature state. Microglia play an important role in brain immune surveillance. They can present antigens in the molecular context of MHC class II expression to CD-4 positive T cells, and are capable of Fc-mediated phagocytosis, and share many common antigens with hematopoietic and tissue macrophages. Upon activation, they act as brain macrophages to clear tissue debris, damaged cells, or microbes, when programmed cell death occurs during brain development or when the CNS is injured. Furthermore, there is evidence that microglia are involved in a variety of physiological and pathological processes in the brain through interaction with neurons, other glial cells, and production of biologically active substances such as growth factors and cytokines.
MM from ScienCell Research Laboratories are isolated from postnatal day 2 C57BL/6 mouse brain. MM are cryopreserved at P0 and delivered frozen. Each vial contains >1 x 10^6 cells in 1 ml volume. MM are characterized by immunofluorescence with antibody to F4/80 and/or CD11b. MM are negative for mycoplasma, bacteria, yeast, and fungi. MM are guaranteed to further culture under the conditions provided by ScienCell Research Laboratories; however, MM are not recommended for expanding or long-term cultures since the cells do not proliferate in regular culture.
Recommended Medium
It is recommended to use Microglia Medium (MM, Cat. #1901) for culturing MM in vitro.
Catalog No. | M1900-57 |
---|---|
Country of Manufacture | United States |
Product Code | MM |
Size/Quantity | 1 x 10^6 cells/vial |
Product Use | This product is for research use only. It is not approved for use in humans, animals, or in vitro diagnostic procedures. |
Storage | Transfer cells directly and immediately from dry ice to liquid nitrogen upon receiving and keep the cells in liquid nitrogen until cell culture is needed for experiments. |
Shipping Info | Dry ice. |
References | [1] Lee, S. C., Liu, W., Brosnan, C. F. and Dickson, D. W. (1992) Characterization of primary human fetal
dissociated central nervous system cultures with an emphasis on microgia. Laboratory Investigation. 67:465-476. [2] Fedoroff, S., Zhai, R. and Novak, J. P. (1997) Microglia and astroglia have a common progenitor cell. J. Neurosci. Res. 50: 477-486. [3] Stoll, G. and Jander, S. (1999) The role of microglia and macrophages in the pathophysiology of the CNS. Prog. Neurobiol. 58:233-247. |
No Publication available at this time
CAT. NO. | CODE | DESCRIPTION | PRICE | Qty | |
---|---|---|---|---|---|
M1900 | MM | Mouse Microglia from CD1 |
$608.00
|
||
MEDIA | |||||
1901 | MM | Microglia Medium |
$139.00
As low as:
$90.00
|
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We are an expanding biotechnology company whose mission is the research and development of cell and cell-related products for experimental use. About Sciencell