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How can we help you today?
Need help with product selection and ordering?
Email us at sales@sciencellonline.com
Need help with scientific inquiries, technical assistance, product applications, and use?
Email us at techsupport@sciencellonline.com
Need help with issues concerning this website?
Email us at webmaster@sciencellonline.com
Have any marketing related inquiries?
Email us at marketing@sciencellonline.com
Need help ordering from abroad?
As the largest cell provider, we are available worldwide.
Please visit our Distributors page to select the company nearest to your location.
We are located at 1610 Faraday Ave, Carlsbad, CA 92008
Call us at (877) 602-8549 or (760) 602-8549
Fax us at (760) 602-8575
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Macrophages are cells differentiated from circulating bone marrow-derived monocytes. The main function of macrophages is to remove cellular debris and destroy invading pathogens. Mouse Splenic Macrophages (MSMa) reside in the spleen and play an critical role in maintaining blood homeostasis. There are three distinct populations of splenic macrophages including: red pulp macrophages, marginal zone macrophages, and marginal zone metallophillic macrophages. MSMa perform iron processing functions and aid in the capture of microbes and viruses in the circulatory system. Recent studies have shown that splenic macrophages contribute to stroke pathology and autoimmune diseases. MSMa are an excellent model for studying macrophage functions under normal physiological and pathological conditions.
MSMa from ScienCell Research Laboratories are isolated from adult C57BL/6 mouse spleen. MSMa are cryopreserved at P0 and delivered frozen. Each vial contains > 1 x 10^6 cells in 1 ml volume. MSMa are characterized by immunofluorescence with antibody to F4/80. MSMa are negative for mycoplasma, bacteria, yeast, and fungi. MSMa are guaranteed to further culture in the conditions provided by ScienCell Research Laboratories; however, MSMa are not recommended for expanding or long-term cultures since the cells do not proliferate in regular culture.
Recommended Medium
It is recommended to use Macrophage Medium (MaM, Cat. #1921) for culturing MSMa in vitro.
Catalog No. | M5550-57 |
---|---|
Country of Manufacture | United States |
Product Code | MSMa |
Size/Quantity | 1 x 10^6 cells/vial |
Product Use | This product is for research use only. It is not approved for use in humans, animals, or in vitro diagnostic procedures. |
Storage | Upon receiving, directly and immediately transfer the cells from dry ice to liquid nitrogen and keep the cells in liquid nitrogen until they are needed for experiments. |
Shipping Info | Dry ice. |
References | [1] Borges da Silva H, Fonseca R, Pereira R, Cassado Ados A, Alvarez J, D'Imperio, Lima M. (2015) "Splenic macrophage subsets and their function during blood-borne infections." Front Immunol. 6:480. [2] Gammella E, Buratti P, Cairo G, Recalcati S. (2014) "Macrophages: central regulators of iron balance." Metallomics. 6(8): 1336-1345. [3] Liu Z, Chen C Li F, Shen J, Yang Y, Leak R, Ji X, Du H, Hu X. (2015) " Splenic responses in ischemic stroke: new insights into stroke pathology." CNS Neurosci Ther. 21(4): 320-326. [4] McGaba T, Karlsson M. (2016) "Apoptotic cell responses in the splenic marginal zone: a paradigm for immunologic reactions to apoptotic antigens with implications for autoimmunity." Immunol Rev. 269(1): 26-43. |
No Publication available at this time
CAT. NO. | CODE | DESCRIPTION | PRICE | Qty | |
---|---|---|---|---|---|
M5550 | MSMa | Mouse Splenic Macrophages from CD1 |
$372.00
|
||
MEDIA | |||||
1921 | MaM | Macrophage Medium |
$139.00
As low as:
$90.00
|
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