Recombinant Human NRG-1 variant

Neuregulin is a signaling protein for ErbB2/ErbB4 receptor heterodimers on the cardiac muscle cells, playing an important role in heart structure and function through inducing ErbB2/ErbB4 receptor phosphorylation and cardiomyocyte differentiation. ScienCell’s Recombinant Human NRG-1 variant is engineered for greater stability, which increases cell proliferation. The rhNRG-1v shares more than 97% amino acid identity with the native human Neuregulin and leaves ErbB2/ErbB4 receptor binding sites unmodified.

Catalog No.	107-10v
Country of Manufacture	United States
Product Code	rhNRG-1v
Size/Quantity	10 μg, 50 μg, or 500 μg
Product Use	This product is for research use only. It is not approved for human or animal use, or for application in clinical or in vitro diagnostic procedures.
Storage	Store at -20°C after receiving. Upon reconstitution, store at 2-8°C for up to one week. For maximal stability, aliquot and store at -20°C. Avoid repeated freeze/ thaw cycles.
Shipping Info	Gel pack
Synonyms	ARIA, GGF, GGF2, HGL, HRG, HRG1, HRG1, MST131, NDF, SMDF
AA Sequence	> 97% sequence homology to native human Neuregulin
Source	Escherichia coli
Molecular Weight	7 kDa, a single non-glycosylated polypeptide chain containing 62 amino acids
Purity	> 95%
Physical Appearance	White lyophilized powder.
Formulation	Lyophilized from a 0.2µm filtered concentrated (1mg/ml) solution in PBS, pH 7.4.
Endotoxin	<0.1 ng/μg of protein (<1 EU/μg)
Reconstitution	Reconstitute in sterile distilled water containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL.