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- Mouse Splenic Macrophages from CD1
Macrophages are cells differentiated from circulating bone marrow-derived monocytes. The main function of macrophages is to remove cellular debris and destroy invading pathogens. Mouse Splenic Macrophages (MSMa) reside in the spleen and play a critical role in maintaining blood homeostasis [1]. There are three distinct populations of splenic macrophages including: red pulp macrophages, marginal zone macrophages, and marginal zone metallophillic macrophages [1, 2]. MSMa perform iron processing functions and aid in the capture of microbes and viruses in the circulatory system [1, 2]. Recent studies have shown that splenic macrophages contribute to stroke pathology and autoimmune diseases [3, 4]. MSMa are an excellent model for studying macrophage functions under normal physiological and pathological conditions.
MSMa from ScienCell Research Laboratories are isolated from adult CD-1 mouse spleen. MSMa are cryopreserved after purification and delivered frozen. Each vial contains > 1 x 10^6 cells in 1 ml volume. MSMa are characterized by immunofluorescence with antibody to F4/80. MSMa are negative for mycoplasma, bacteria, yeast, and fungi. MSMa are guaranteed to further culture in the conditions provided by ScienCell Research Laboratories; however, MSMa are not recommended for expanding or long-term cultures since the cells do not proliferate in regular culture.
Catalog No. | M5550 |
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Country of Manufacture | United States |
Product Code | MSMa |
Size/Quantity | - |
Product Use | This product is for research use only. It is not approved for use in humans, animals, or in vitro diagnostic procedures. |
Storage | - |
Shipping Info | - |
References | [1] Borges da Silva H, Fonseca R, Pereira R, Cassado Ados A, Alvarez J, D'Imperio, Lima M. (2015) "Splenic macrophage subsets and their function during blood-borne infections." Front Immunol. 6:480. [2] Gammella E, Buratti P, Cairo G, Recalcati S. (2014) "Macrophages: central regulators of iron balance." Metallomics. 6(8): 1336-1345. [3] Liu Z, Chen C Li F, Shen J, Yang Y, Leak R, Ji X, Du H, Hu X. (2015) " Splenic responses in ischemic stroke: new insights into stroke pathology. " CNS Neurosci Ther. 21(4): 320-326. [4] McGaba T, Karlsson M. (2016) "Apoptotic cell responses in the splenic marginal zone: a paradigm for immunologic reactions to apoptotic antigens with implications for autoimmunity." Immunol Rev. 269(1): 26-43. |
No Publication available at this time
CAT. NO. | CODE | DESCRIPTION | PRICE | Qty | |
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M5550-57 | MSMa | Mouse Splenic Macrophages from C57BL/6 |
$379.00
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MEDIA | |||||
1921 | MaM | Macrophage Medium |
$126.00
As low as:
$81.00
|