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- Mouse Macrophages from C57BL/6
Macrophages are cells differentiated from circulating bone marrow-derived monocytes. In the bone marrow and subsequestly in the blood and tissues, monocytes undergo a cascade of maturation that culminate in morphologically and functionally mature tissue macrophages. The main function of macrophages is to remove cellular debris and destroy invading pathogens. They phagocytize invading microorganisms, and scavenge dead, damaged cells and cellular debris. Macrophages can be identified by the specific expression of several cell surface proteins including CD14, CD11b, F4/80 (mice)/EMR1 (human), MAC-1/MAC-3, and CD68 by flow cytometry or immunohistochemical staining.
MMa-bm from ScienCell Research Laboratories are isolated from adult C57BL/6 mouse bone marrow. MMa-bm are harvested at P0 and delivered frozen. Each vial contains >1 x 10^6 cells in 1 ml volume. MMa-bm are characterized by immunofluorescence with antibody specific to F4/80 and/or CD11b. MMa-bm are negative for mycoplasma, bacteria, yeast, and fungi. MMa-bm are guaranteed to further culture under the conditions provided by ScienCell Research Laboratories; however, MMa-bm are not recommended for expanding or long-term cultures since the cells do not proliferate in regular culture.
Recommended Medium
It is recommended to use Macrophage Medium (MaM, Cat. #1921) for culturing MMa-bm in vitro.
| Catalog No. | M1920-57 |
|---|---|
| Country of Manufacture | United States |
| Product Code | MMa-bm |
| Size/Quantity | 1 x 10^6 cells/vial |
| Product Use | This product is for research use only. It is not approved for use in humans, animals, or in vitro diagnostic procedures. |
| Storage | Transfer cells directly and immediately from dry ice to liquid nitrogen upon receiving and keep the cells in liquid nitrogen until cell culture is needed for experiments. |
| Shipping Info | Dry ice. |
| References | [1]. Cline MJ and Sumner MA. (1972) Bone Marrow Macrophage Precursors. I. Some Functional Characteristics of the Early Cells of the Mouse Macrophage Series. Blood. 40: 62-69. [2]. Wynn TA and Barron L. (2010) Macrophages: master regulators of inflammation and fibrosis. Semin Liver Dis. 30: 245-57. [3]. Gordon S and Taylor RP. (2005) Monocyte and macrophage heterogeneity. Nature Reviews Immunology. 5: 953-964. |
Product Sheets
M1920-57-2 (2 Million Cells per Vial)
Certificates of Analysis
For a specific lot number, please search below:
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| CAT. NO. | CODE | DESCRIPTION | PRICE | Qty | |
|---|---|---|---|---|---|
| M1920 | MMa-bm | Mouse Macrophages from CD1 |
$372.00
|
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| MEDIA | |||||
| 1921 | MaM | Macrophage Medium |
$139.00
As low as:
$90.00
|
