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- Human Pancreatic Stellate Cells
Pancreatic Stellate Cells (HPaSteC) are the main fibroblastic cells of the pancreas. HPaSteC are responsible for the synthesis and the degradation of the extracellular matrix proteins that promote tissue repair. They are found adjacent to pancreatic acinar cells and around small pancreatic ducts and blood vessels. When HPaSteC are activated, they assume myofibroblast-like morphology and secrete excessive amounts of extracellular matrix proteins, which can lead to desmoplasia in chronic pancreatitis and adenocarcinoma. Recent studies have shown that HPaSteC can also act as progenitor cells, immune cells, and intermediaries in exocrine pancreatic secretion. Additionally, HPaSteC stimulate pancreatic cancer proliferation, inhibit apoptosis, and enhance angiogenesis. HPaSteC are the ideal model for studying pancreatic tumor formation and they can be used to develop novel therapies for treatment of chronic pancreatitis and adenocarcinoma.
HPaSteC from ScienCell Research Laboratories are isolated from human pancreas. HPaSteC are cryopreserved at passage one and delivered frozen. Each vial contains >5 x 10^5 cells in 1 ml volume. HPaSteC are characterized by immunofluorescence with antibodies specific to α-smooth muscle actin. HPaSteC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HPaSteC are guaranteed to further expand for 15 population doublings under the conditions provided by ScienCell Research Laboratories
Recommended Medium
It is recommended to use Stellate Cell Medium (SteCM, Cat. #5301) for the culturing of HPaSteC in vitro.
| Catalog No. | 3830 |
|---|---|
| Country of Manufacture | United States |
| Product Code | HPaSteC |
| Size/Quantity | 5 x 10^5 cells/vial |
| Product Use | This product is for research use only. It is not approved for use in humans, animals, or in vitro diagnostic procedures. |
| Storage | Directly and immediately transfer cells from dry ice to liquid nitrogen upon receiving and keep the cells in liquid nitrogen until cell culture is needed for experiments. |
| Shipping Info | Dry ice. |
| References | [1] Erkan, M., Hausmann, S., Michalski, C., Schlitter, M., Fingerle, A,. Friess, H., and Kleeff, J. (2012). How fibrosis influences imaging and surgical decision in pancreatic cancer. Front. Physio. 3:389. [2] Apte, M., Pirola, R., and Wilson, J. (2012). Pancreatic stellate sells: A starring role in normal and diseased pancreas. Front. Physio. 3:344. [3] Mato, E., Lucas, M., Petriz, J., Gomis, R., and Novials, A. (2009). Identi?cation of a pancreatic stellate cell population with properties of progenitor cells: new role for stellate cells in the pancreas. Biochem. J. 421:181. [4] Shimizu, K., Kobayashi, M., Tahara, J., and Shiratori, K. (2005). Cytokines and peroxisome proliferator-activated receptor gamma ligand regulate phagocytosis by pancreatic stellate cells. Gastroenterology. 128: 2105. [5] Phillips, P. A.,Yang, L., Shulkes, A., Vonlaufen, A., Poljak, A., Bustamante, S., Warren, A., Xu, Z.,Guilhaus, M., Pirola, R.,Apte, M. V., and Wilson, J. S. (2010). Pancreatic stellate cells produce acetylcholine and may play a role in pancreatic exocrine secretion. Proc. Natl. Acad. Sci. U.S.A. 107:17397. |
38301.) Robinson, B.K., Cortes, E., Rice, A.J., Sarper, M. & del R?o Hern?ndez, A.(2016) 'Quantitative analysis of 3D extracellular matrix remodelling by pancreatic stellate cells' Biology Open. VOL 5
2.) Jakubowska, M.A., Ferdek, P.E., Gerasimenko, O.V., Gerasimenko, J.V. & Petersen, O.H.(2016) 'Nitric oxide signals are interlinked with calcium signals in normal pancreatic stellate cells upon oxidative stress and inflammation' Open Biology. VOL 6
ScienCell Research Laboratories (SRL) takes pride in being a resource for researchers all over the world. The publications listed here are not meant as an endorsement or confirmation of the reliability of the research methods. Our sole intention of sharing the research publications listed here is to provide research related insights and innovations of our products with other researchers.
| CAT. NO. | CODE | DESCRIPTION | PRICE | Qty | |
|---|---|---|---|---|---|
| MEDIA | |||||
| 5301 | SteCM | Stellate Cell Medium |
$135.00
As low as:
$90.00
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| MOLECULAR BIOLOGY | |||||
| 3834 | HPaSteC cDNA | Human Pancreatic Stellate Cell cDNA |
$453.00
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| 3835 | HPaSteC tRNA | Human Pancreatic Stellate Cell Total RNA |
$401.00
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| 3839 | HPaSteC gDNA | Human Pancreatic Stellate Cell Genomic DNA |
$438.00
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