Bovine Hypothalamus Extract (BHE-1)

The hypothalamus is a critical brain region linking the nervous and endocrine systems through the pituitary gland. The hypothalamus regulates vital homeostatic processes, including metabolism, bodily temperature, reproductive behaviors and food and water intake. Bovine hypothalamus extract (BHE) contains numerous growth factors and hormones that promote endothelial [1], epithelial [2, 3], and hybridoma cell proliferation [4], especially in low serum and serum-free media.

Catalog No.	0603
Country of Manufacture
Product Code	BHE-1
Size/Quantity	5 mg/ml; 1 ml
Product Use	This product is for research use only. It is not approved for use in humans, animals, or in vitro diagnostic procedures.
Storage	Store BHE between -20°C and -80°C until ready for use. Aliquot to avoid repeated freeze-thaw cycles.
Shipping Info	Dry ice.
References	[1] Maciag T, Cerundolo J, Ilsley S, Kelley PR, Forand R. (1979) "An endothelial cell growth factor from bovine hypothalamus: Identification and partial characterization". Proc. Natl. Acad. Sci. USA 76: 5674-5678. [2] Gilchrest BA, Calhoun JK, Maciag T. (1982) "Attachment and growth of human keratinovytes in a serum-free environment". Journal of Cellular Physiology 112: 197-206. [3] Maciag T, Nemore RE, Weinstein R, Gilchrest BA. (1981) "An endocrine approach to the control of epidermal growth: serum-free cultivation of human keratinocytes". Science 211: 1452-1454. [4] Pintus C, Ransom JH, Evans CH. (1983) "Endothelial cell growth supplement: a cell cloning factor that promotes the growth of monoclonal antibody producing hybridoma cells". J Immunol Methods 61: 195-200. Caution: If handled improperly, some components of this product may present a health hazard. Take appropriate precautions when handling this product, including the wearing of protective clothing and eyewear. Dispose of properly