- Home /
- Rat Brain Vascular Pericytes
Brain Vascular Pericytes (BVP) are perivascular cells that are closely associated with the endothelium of capillaries and other small vessels [1]. BVP, located between endothelial cells and astrocytes in the brain, communicate with other cells by extending long cytoplasmic processes which wrap around the capillaries [1, 2]. BVP participate in a variety of processes including angiogenesis, endothelial cell survival, regulation of capillary blood flow, and establishment and maintenance of the blood-brain barrier [3, 4]. Pericyte dysregulation has been linked to several pathological conditions such as hypertension, diabetic retinopathy, atherosclerosis, multiple sclerosis, Alzheimer’s disease, and tumor angiogenesis [2, 4]. The unique and diverse functions of BVP make them novel candidates for cell therapy in regenerative medicine. Cultured primary rat BVP (RBVP) are a useful in vitro model for understanding the molecular mechanisms of blood-brain barrier regulation and for studying a wide variety of central nervous system diseases.
RBVP from ScienCell Research Laboratories are isolated from adult rat brain. RBVP are cryopreserved at passage one and delivered frozen. Each vial contains >5 x 10^5 cells in 1 ml volume. RBVP are characterized by immunofluorescence with antibody specific to platelet-derived growth factor-ß (PDGF receptor-ß) and α-smooth muscle actin. RBVP are negative for mycoplasma, bacteria, yeast, and fungi. RBVP are guaranteed to further expand for 5 population doublings under the conditions provided by ScienCell Research Laboratories.
Recommended Medium
It is recommended to use Pericyte Medium (PM, Cat. #1201) for culturing RBVP in vitro.Catalog No. | R1200 |
---|---|
Country of Manufacture | United States |
Product Code | RBVP |
Size/Quantity | 5 x 10^5 cells/vial |
Product Use | This product is for research use only. It is not approved for use in humans, animals, or in vitro diagnostic procedures. |
Storage | Upon receiving, directly and immediately transfer the cells from dry ice to liquid nitrogen and keep the cells in liquid nitrogen until they are needed for experiments. |
Shipping Info | Dry ice. |
References | [1] Dore-Duffy P, Cleary K. (2011) "Morphology and properties of pericytes." Methods Mol Biol. 686:49-68. [2] Allt G, Lawrenson JG. (2001) "Pericytes: cell biology and pathology." Cells Tissues Organs. 169: 1-11. [3] Daneman R, Zhou L, Kebede A, Barres B. (2010) "Pericytes are required for blood-brain barrier integrity during embryogenesis." Nature. 468:562-566. [4] Kutcher M, Herman I. (2009) "The pericyte: cellular regulator of microvascular blood flow." Microvasc Res. 77: 235-246. |
No Publication available at this time
CAT. NO. | CODE | DESCRIPTION | PRICE | Qty | |
---|---|---|---|---|---|
1200 | HBVP | Human Brain Vascular Pericytes |
$718.00
|
||
M1200 | MBVP | Mouse Brain Vascular Pericytes from CD1 |
$552.00
|
||
MEDIA | |||||
1201 | PM | Pericyte Medium |
$120.00
As low as:
$81.00
|
||
REAGENTS | |||||
0303 | DPBS | Dulbecco's Phosphate-Buffered Saline, 500 ml |
$16.00
|
||
0403 | PLL | Poly-L-Lysine, 1 mg/ml |
$16.00
|
||
0103 | T/E | Trypsin/EDTA Solution, 0.25% |
$21.00
|
||
0113 | TNS | Trypsin Neutralization Solution, 100 ml |
$21.00
|