- Home /
- Human Hair Inner Root Sheath Cells
The inner root sheath (IRS) of human hair follicles consists of three concentric cell layers: the cuticle, Huxley's layer, and Henle's layer. All three layers are formed from the peripheral mass of matrix cells in the hair bulb. The formation of the IRS during the evolution of the mammalian epidermis allowed the physiological exit of hairs produced inside the skin. Its dimension and curvature largely determine the shape of the hair. Previous studies have reported the expression of specific type II epithelial keratins and a unique fibroblast growth factor (FGF) in the IRS, suggesting a preferential role for these proteins in hair development.
HHIRSC from ScienCell Research Laboratories are isolated from human scalp. HHIRSC are cryopreserved at passage one and delivered frozen. Each vial contains >5 x 10^5 cells in 1 ml volume. HHIRSC are characterized by their mesenchymal cell morphology and immunofluorescence with antibodies specific to fibronectin and/or CD105. HHIRSC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi. HHIRSC are guaranteed to further expand for 10 population doublings under the conditions provided by ScienCell Research Laboratories.
Recommended Medium
It is recommended to use Mesenchymal Cell Medium (MCM, Cat. #7501) for culturing HHIRSC in vitro.
| Catalog No. | 2430 |
|---|---|
| Country of Manufacture | United States |
| Product Code | HHIRSC |
| Size/Quantity | 5 x 10^5 cells/vial |
| Product Use | This product is for research use only. It is not approved for use in humans, animals, or in vitro diagnostic procedures. |
| Storage | Directly and immediately transfer cells from dry ice to liquid nitrogen upon receiving and keep the cells in liquid nitrogen until cell culture needed for experiments. |
| Shipping Info | Dry ice. |
| References | [1] Langbein, L., Rogers, M.A., Praetzel, S., Winter, H., Schweizer, J. (2003) K6irs1, K6irs2, K6irs3, and K6irs4 represent the inner-root-sheath-specific type II epithelial keratins of the human hair follicle. J Invest Dermatol. 120:512-22. [2] Nakatake, Y., Hoshikawa, M., Asaki, T., Kassai, Y., Itoh, N. (2001) Identification of a novel fibroblast growth factor, FGF-22, preferentially expressed in the inner root sheath of the hair follicle. Biochim Biophys Acta. 1517:460-463. |
2430No Publication available at this time
| CAT. NO. | CODE | DESCRIPTION | PRICE | Qty | |
|---|---|---|---|---|---|
| MEDIA | |||||
| 7501 | MSCM | Mesenchymal Stem Cell Medium |
$139.00
As low as:
$90.00
|
||
| MOLECULAR BIOLOGY | |||||
| 2434 | HHIRSC cDNA | Human Hair Inner Root Sheath Cell cDNA |
$453.00
|
||
| 2435 | HHIRSC tRNA | Human Hair Inner Root Sheath Cell Total RNA |
$401.00
|
||
| 2436 | HHIRSC Lysate | Human Hair Inner Root Sheath Cell Lysate |
$438.00
|
||
| 2437 | HHIRSC miRNA | Human Hair Inner Root Sheath Cell MicroRNA |
$374.00
|
||
| 2439 | HHIRSC gDNA | Human Hair Inner Root Sheath Cell genomic DNA |
$438.00
|
||
