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- Human Mammary Epithelial Cells
Mammary epithelial cells (MEpiC) lie within the alveolar lumen of the breast lobules, which together with mammary ducts and adipose tissues, form a complex network in the mammary gland. MEpiC respond to various growth factors and hormonal cues and undergo changes in growth, invasion, and differentiation during pre- and postnatal stages, puberty, and pregnancy. Aberrant levels of hormones and extracellular matrix composition, and other genetic factors have been shown to induce uncontrolled proliferation of MEpiC, resulting in breast cancer development. Understanding the cellular properties of MEpiC will help identify the disease mechanisms in breast cancer and the new targets for therapeutic development.
HMEpiC from ScienCell Research Laboratories are isolated from human breast. HMEpiC are cryopreserved at passage one and delivered frozen. Each vial contains >5 x 10^5 cells in 1 ml volume. HMEpiC are characterized by immunofluorescence with antibodies specific to cytokeratin18 and/or cytokeratin-19. HMEpiC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi. HMEpiC are guaranteed to further expand for 10 population doublings under the conditions provided by ScienCell Research Laboratories.
Recommended Medium
It is recommended to use Mammary Epithelial Cell Medium (MEpiCM, Cat. #7611) for culturing HMEpiC in vitro.
| Catalog No. | 7610 |
|---|---|
| Country of Manufacture | United States |
| Product Code | HMEpiC |
| Size/Quantity | 5 x 10^5 cells/vial |
| Product Use | This product is for research use only. It is not approved for use in humans, animals, or in vitro diagnostic procedures. |
| Storage | Directly and immediately transfer cells from dry ice to liquid nitrogen upon receiving and keep the cells in liquid nitrogen until cell culture needed for experiments. |
| Shipping Info | Dry ice. |
| References | [1]. Topper, Y.J., Freeman, C.S. (1980) Multiple hormone interactions in the developmental biology of the mammary gland. Physiol Rev 60:1049-106. [2]. Hennighausen, L., Robinson, G.W. (2001) Signaling pathways in mammary gland development. Dev Cell 1:467-475. |
76101.) Zhang L, Webster TJ. (2013) "Effects of chemically modified nanostructured PLGA on functioning of lung and breast cancer cells." Int J Nanomedicine. 8: 1907-19.
2.) Lu RM, Chen MS, Chang DK, Chiu CY, Lin WC, Yan SL, Wang YP, Kuo YS, Yeh CY, Lo A, Wu HC. (2013) "Targeted drug delivery systems mediated by a novel Peptide in breast cancer therapy and imaging." PLoS One. 8: e66128.
3.) Fong C, Weerawardena A, Sagnella SM, Mulet X, Krodkiewska I, Chong J, Drummond CJ. (2011) "Monodisperse Nonionic Isoprenoid-Type Hexahydrofarnesyl Ethylene Oxide Surfactants: High Throughput Lyotropic Liquid Crystalline Phase Determination." Langmuir.
4.) Gong X, Moghaddam MJ, Sagnella SM, Conn CE, Danon SJ, Waddington LJ, Drummond CJ. (2011) "Lamellar crystalline self-assembly behaviour and solid lipid nanoparticles of a palmityl prodrug analogue of Capecitabine-A chemotherapy agent." Colloids Surf B Biointerfaces. 85: 349-59.
5.) Guevara-Aguirre J, Balasubramanian P, Guevara-Aguirre M, Wei M, Madia F, Cheng CW, Hwang D, Martin-Montalvo A, Saavedra J, Ingles S, de Cabo R, Cohen P, Longo VD. (2011) "Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans." Sci Transl Med. 3: 70ra13.
6.) Sagnella SM, Conn CE, Krodkiewska I, Moghaddam M, Drummond CJ. (2010) "Endogenous nonionic saturated monoethanolamide lipids: solid state, lyotropic liquid crystalline, and solid lipid nanoparticle dispersion behavior." J Phys Chem B. 114: 1729-37.
7.) Huang Y, Song N, Ding Y, Yuan S, Li X, Cai H, Shi H, Luo Y. (2009) "Pulmonary vascular destabilization in the premetastatic phase facilitates lung metastasis." Cancer Res. 69: 7529-37.
ScienCell Research Laboratories (SRL) takes pride in being a resource for researchers all over the world. The publications listed here are not meant as an endorsement or confirmation of the reliability of the research methods. Our sole intention of sharing the research publications listed here is to provide research related insights and innovations of our products with other researchers.
| CAT. NO. | CODE | DESCRIPTION | PRICE | Qty | |
|---|---|---|---|---|---|
| MEDIA | |||||
| 7611 | MEpiCM | Mammary Epithelial Cell Medium |
$135.00
As low as:
$90.00
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| MOLECULAR BIOLOGY | |||||
| 7614 | HMEpiC cDNA | Human Mammary Epithelial Cell cDNA |
$453.00
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| 7615 | HMEpiC tRNA | Human Mammary Epithelial Cell Total RNA |
$401.00
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| 7616 | HMEpiC Lysate | Human Mammary Epithelial Cell Lysate |
$438.00
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| 7617 | HMEpiC miRNA | Human Mammary Epithelial Cell MicroRNA |
$374.00
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| 7619 | HMEpiC gDNA | Human Mammary Epithelial Cell Genomic DNA |
$438.00
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