Recombinant Human Platelet-derived Growth Factor-BB

Platelet-derived growth factor (PDGF) presenting in serum but absent from plasma was first discovered in animal study by Lynch and co-workers in the late 1980s. It is a disulfide-linked dimer consisting of two peptides-chain A and chain B. PDGF has three subforms: PDGF-AA, PDGF-BB, PDGF-AB. It is involved in a number of biological processes, including hyperplasia, embryonic neuron development, chemotaxis, and respiratory tubule epithelial cell development. The function of PDGF is mediated by two receptors (PDGFR-α and PDGFR-β).

Catalog No.	105-10
Country of Manufacture	United States
Product Code	rhPDGF-BB
Size/Quantity	10 μg, 50 μg, or 500 μg
Product Use	This product is for research use only. It is not approved for human or animal use, or for application in clinical or in vitro diagnostic procedures.
Storage	Store at -20°C after receiving. Upon reconstitution, store at 2-8°C for up to one week. For maximal stability, aliquot and store at -20°C. Avoid repeated freeze/ thaw cycles.
Shipping Info	Gel pack
Synonyms	Platelet-Derived Growth Factor-BB, Glioma-derived growth factor (GDGF), Osteosarcoma-derived Growth Factor (ODGF)
AA Sequence	(monomer) SLGSLTIAEP AMIAECKTRT EVFEISRRLI DRTNANFLVW PPCVEVQRCS GCCNNRNVQC RPTQVQLRPV VRKIEIVRK KPIFKKATVT LEDHLACKCE TVAAARPVT
Source	Pichia pastoris
Molecular Weight	Approximately 24.3 kDa, a disulfide-linked homodimeric protein containing two 110 amino acids residues polypeptide.
Purity	> 95% by SDS-PAGE
Physical Appearance	White lyophilized powder.
Formulation	Lyophilized from a 0.2µm filtered concentrated (1mg/ml) solution in PBS, pH 7.4.
Endotoxin	<0.1 ng/μg of protein (<1 EU/μg)
Reconstitution	Reconstitute in sterile distilled water containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL.